Publications

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2022

Wohlfarter Y, Eidelpes R, Yu RD, Sailer S, Koch J, Karall D, Scholl-Bürgi S, Amberger A, Hillen HS, Zschocke J, Keller MA. Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism. Cell Mol Life Sci. 2022 Oct 22;79(11):562. doi: 10.1007/s00018-022-04579-6. PMID: 36271951; PMCID: PMC9587951.

Bögershausen N, Krawczyk HE, Jamra RA, Lin SJ, Yigit G, Hüning I, Polo AM, Vona B, Huang K, Schmidt J, Altmüller J, Luppe J, Platzer K, Dörgeloh BB, Busche A, Biskup S, Mendes MI, Smith DEC, Salomons GS, Zibat A, Bültmann E, Nürnberg P, Spielmann M, Lemke JR, Li Y, Zenker M, Varshney GK, Hillen HS, Kratz CP, Wollnik B. WARS1 and SARS1: Two tRNA synthetases implicated in autosomal recessive microcephaly. Hum Mutat. 2022 Oct;43(10):1454-1471. doi: 10.1002/humu.24430. Epub 2022 Jul 21. PMID: 35790048.

Bhatta A, Hillen HS. Structural and mechanistic basis of RNA processing by protein-only ribonuclease P enzymes. Trends Biochem Sci. 2022 Nov;47(11):965-977. doi: 10.1016/j.tibs.2022.05.006. Epub 2022 Jun 18. PMID: 35725940.

Lavdovskaia E, Hillen HS, Richter-Dennerlein R. Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis. Trends Cell Biol. 2022 Mar;32(3):182-185. doi: 10.1016/j.tcb.2021.09.004. Epub 2021 Oct 8. PMID: 34635384.

2021

Bhatta A, Dienemann C, Cramer P, Hillen HS. Structural basis of RNA processing by human mitochondrial RNase P. Nat Struct Mol Biol. 2021 Sep;28(9):713-723. doi: 10.1038/s41594-021-00637-y. Epub 2021 Sep 6. PMID: 34489609; PMCID: PMC8437803.

Jochheim FA, Tegunov D, Hillen HS, Schmitzová J, Kokic G, Dienemann C, Cramer P. The structure of a dimeric form of SARS-CoV-2 polymerase. Commun Biol. 2021 Aug 24;4(1):999. doi: 10.1038/s42003-021-02529-9. PMID: 34429502; PMCID: PMC8385044.

Kabinger F, Stiller C, Schmitzová J, Dienemann C, Kokic G, Hillen HS, Höbartner C, Cramer P. Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nat Struct Mol Biol. 2021 Sep;28(9):740-746. doi: 10.1038/s41594-021-00651-0. Epub 2021 Aug 11. PMID: 34381216; PMCID: PMC8437801.

Hillen HS#, Lavdovskaia E, Nadler F, Hanitsch E, Linden A, Bohnsack KE, Urlaub H, Richter-Dennerlein R#. Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling. Nat Commun. 2021 Jun 16;12(1):3672. doi: 10.1038/s41467-021-23702-y. PMID: 34135319; PMCID: PMC8209004.

Hillen HS. Structure and function of SARS-CoV-2 polymerase. Curr Opin Virol. 2021 Jun;48:82-90. doi: 10.1016/j.coviro.2021.03.010. Epub 2021 Apr 6. PMID: 33945951; PMCID: PMC8023233.

Hillen HS*, Markov DA*, Wojtas ID, Hofmann KB, Lidschreiber M, Cowan AT, Jones JL, Temiakov D, Cramer P, Anikin M. The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs. Proc Natl Acad Sci U S A. 2021 Apr 13;118(15):e2009329118. doi: 10.1073/pnas.2009329118. PMID: 33876744; PMCID: PMC8054023.

Kokic G*, Hillen HS*, Tegunov D*, Dienemann C*, Seitz F, Schmitzova J, Farnung L, Siewert A, Höbartner C, Cramer P. Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nat Commun. 2021 Jan 12;12(1):279. doi: 10.1038/s41467-020-20542-0. PMID: 33436624; PMCID: PMC7804290.

2020

Bonekamp NA, Peter B, Hillen HS, Felser A, Bergbrede T, Choidas A, Horn M, Unger A, Di Lucrezia R, Atanassov I, Li X, Koch U, Menninger S, Boros J, Habenberger P, Giavalisco P, Cramer P, Denzel MS, Nussbaumer P, Klebl B, Falkenberg M, Gustafsson CM, Larsson NG. Small-molecule inhibitors of human mitochondrial DNA transcription. Nature. 2020 Dec;588(7839):712-716. doi: 10.1038/s41586-020-03048-z. Epub 2020 Dec 16. PMID: 33328633.

Hillen HS*, Kokic G*, Farnung L*, Dienemann C*, Tegunov D, Cramer P*. Structure of replicating SARS-CoV-2 polymerase. Nature. 2020 Aug;584(7819):154-156. doi: 10.1038/s41586-020-2368-8. Epub 2020 May 21. PMID: 32438371.

2019

Hillen HS*, Bartuli J*, Grimm C, Dienemann C, Bedenk K, Szalay AA, Fischer U, Cramer P. Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes. Cell. 2019 Dec 12;179(7):1525-1536.e12. doi: 10.1016/j.cell.2019.11.023. PMID: 31835031.https://pubmed.ncbi.nlm.nih.gov/31835031/

Grimm C*, Hillen HS*, Bedenk K, Bartuli J, Neyer S, Zhang Q, Hüttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Böttcher B, Szalay AA, Cramer P, Fischer U. Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes. Cell. 2019 Dec 12;179(7):1537-1550.e19. doi: 10.1016/j.cell.2019.11.024. PMID: 31835032.

2018

Hillen HS#, Temiakov D, Cramer P#. Structural basis of mitochondrial transcription. Nat Struct Mol Biol. 2018 Sep;25(9):754-765. doi: 10.1038/s41594-018-0122-9. Epub 2018 Sep 6. PMID: 30190598; PMCID: PMC6583890.

2017

Hillen HS, Morozov YI, Sarfallah A, Temiakov D, Cramer P. Structural Basis of Mitochondrial Transcription Initiation. Cell. 2017 Nov 16;171(5):1072-1081.e10. doi: 10.1016/j.cell.2017.10.036. PMID: 29149603; PMCID: PMC6590061.

Hillen HS, Parshin AV, Agaronyan K, Morozov YI, Graber JJ, Chernev A, Schwinghammer K, Urlaub H, Anikin M, Cramer P, Temiakov D. Mechanism of Transcription Anti-termination in Human Mitochondria. Cell. 2017 Nov 16;171(5):1082-1093.e13. doi: 10.1016/j.cell.2017.09.035. Epub 2017 Oct 12. PMID: 29033127; PMCID: PMC5798601.